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The NHS Confederation says the Government ‘should be under no illusion that the NHS will be harmed’ by the potential failure to agree a deal.

"It’s a tragedy what’s happening in Britain, and this Brexit is a tragedy, we see it more and more every day,” French commissioner Thierry Breton said.

The campaign has been launched by the Blue Collar Conservative group of MPs who helped Boris Johnson sweep through the Labour heartlands a year ago.

“All we need now is for Jacob Rees-Mogg and the Government to abandon their baseless and dangerous opposition to remote sittings and we can move forward without putting anyone at unnecessary risk.”

Simon Hoare - chair of the Commons’ Northern Ireland select committee - added his voice to growing calls to ‘stop the clock’ on post-Brexit trade talks with Brussels, claiming that it was “time for maturity”.

The pound could see a “severe downside shock if there is no deal by Christmas”.

Scotland’s First Minister, Nicola Sturgeon, said it would be “unconscionable” to add a no-deal exit from the EU’s trading arrangements to the current difficulties caused by the mutant coronavirus strain.

How it started.........How it's, oh never mind

After lead negotiators Michel Barnier and Lord Frost met in Brussels on Sunday, a UK source said discussions had been “difficult”.