Harding formally applied to succeed Sir Simon Stevens atop the health service last week.
Ministers set out plans for a “system and culture change” after convictions for rape and lesser offences in England and Wales hit a record low.
“I am motivated by support for equality, social justice and internationalism. That is the Labour brand,” the former Speaker told the Observer.
It comes as polling expert Sir John Curtice told BBC Radio 4’s Today programme that he made it the “worst Labour performance in any by-election”.
He is facing trial accused of sexually assaulting a 15-year-old boy.
"On Thursday, 38,000 voters went to the polls, to pick one MP. On the same day, three hereditary aristocrats were put into the Lords by just 36 Conservative hereditary peers."
“This is the first big Remain constituency by-election in England, and I think the dismal ‘embrace Brexit’ mantra may be at least partially to blame," Rejoin EU's leader has said.
“Potentially one of the most embarrassing things I’ve seen,” one Twitter user announced.
Sir Simon Stevens refused to say whether he agrees with the prime minister that Matt Hancock is "useless".
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